Monocrotaline introduction and use What precautions_FAQ_Weikeqi Biological Technology
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Monocrotaline introduction and use What precautions
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Monocrotaline introduction and use What precautions   Classification:FAQ Release:2016-05-24 10:59:35   Read:(1299)
Monocrotaline (Monocrotaline), the trade name of a large green leaf Crotalaria base, he can Luo Lin, A prime agricultural auspicious, auspicious agricultural base, agricultural base auspicious. A variety of experimental tumor inhibition, the major clinical trial in skin squamous cell carcinoma and basal cell carcinoma, good effect, acute leukemia, cervical and penile cancer are also effective. The drugs are classified to other drugs classification.
Monocrotaline as a pyrrolizidine alkaloid formula C16H23NO6. It exists in lily genus, in his false blue, bell beans, big leaf Crotalaria and contain it in agricultural auspicious, auspicious in agricultural seeds containing up to 0.4%, is an important agricultural resource extraction auspicious base . 1935 W.M. Neal and L.L. Lusuo Fu was first isolated from a beautiful lily out.
Side effects lily base (adverse reactions)
Severe systemic toxicity, including bone marrow suppression, liver toxicity, gastrointestinal reactions, urinary tract irritation symptoms, topical less toxic.
Taking matters to be noted Monocrotaline
1. gastrointestinal reactions are nausea, vomiting, loss of appetite and so on.
2. bone marrow suppression, make platelets, leukopenia.
3. liver and kidney damage and urinary tract irritation symptoms.
4. In the course of treatment should pay attention to changes in blood.
Dosage lily base
Note: Different companies produce the same kinds of drugs may be due to different packaging sizes have different amounts of medication. Dosage herein are for reference only. If in doubt, see the instructions that came with the drug or to ask doctors.
Daily 50 ~ 100mg, dissolved in isotonic saline or 5% glucose for intravenous injection or intravenous infusion, a total of about 750 ~ 1500mg course of treatment. Intramuscular: every 15 ~ 30mg, once daily, 600mg total course of treatment. Topical powder daily 15 ~ 80mg, total 750 ~ 1500mg course of treatment.
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